Endocrine Abstracts

Rationale and purpose: Glucose tolerance often changes in patients with pancreatic lesions and usually worsens after distal pancreatectomy; however, factors affecting interindividual variation in progression are unclear. Our study aimed to investigate the glyco-metabolic status in a series of patients undergoing pancreatic resection for treatment of benign or malignant lesions and risk factors involved in the developing T3cDM.Methods: We conducted an obs...

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

Lipodystrophy syndromes are a rare and heterogeneous disease characterized by loss of subcutaneous adipose tissue, deposition of fat in ectopic areas, and consequently metabolic impairment, and its recognition is based on physical examination and clinical history. Because of the complexity of the disease, pregnancy represents a dainty and challenging event, still understudied. Here we report a case of a 28 year-old Caucasian female followed for type 2 diabetes and hypertriglyc...

Background: The clinical burden of Klinefelter Syndrome (KS) is not limited to the impairment of gonadal function and an increased prevalence of cardio-metabolic, endocrinological and oncological diseases, but also involve several cognitional, behavioural and psychological issues. Because of the wide heterogeneity in clinical phenotype, the diagnosis of KS is still challenging, resulting in a significant number of patients to remain undiagnosed or to have a late diagnosis. Ver...

Aim: To evaluate: 1) clinical and epidemiological characteristics of outpatients transitioned from Pediatrics Endocrine (PED) to Adult Endocrine Department (AED) in a tertiary Centre; 2) transition process characteristics, and predictive factors of drop-out.Patients and methods: Demographic, clinical, and transition features of 170 consecutive patients with paediatric onset of chronic endocrine or metabolic disease (excluded type 1 diabetes) who transiti...

Background: Data on the relationship between type 2 diabetes (T2D) and cancer consistently suggests the involvement of metabolic mechanisms such as inflammation, obesity, and glucose alteration. These mechanisms, including the activation of factors like IGF-1 or m-TOR, may influence the development of cancer.Aim: Our study had two main objectives. Firstly, we aimed to investigate the relationship between specific identifiable factors associated with T2D ...